## Abstract Mitochondrial DNA (mtDNA) mutations were reported in different cancers. However, the nature and role of mtDNA mutation in neverβsmoker lung cancer patients including patients with epidermal growth factor receptor (__EGFR__) and __KRAS__ gene mutation are unknown. In the present study, w
DNA repair gene polymorphisms and benefit from gefitinib in never-smokers with lung adenocarcinoma
β Scribed by Ji-Youn Han; Kyong-Ah Yoon; Jae Hee Park; Young Joo Lee; Geon Kook Lee; Jong Hee Han; Sung Jin Yoon; Tak Yun; Heung Tae Kim; Jin Soo Lee
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 166 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Single nucleotide polymorphisms (SNPs) were searched for in 36 genes involved in diverse DNA repair pathways, and 50 nonsynonymous (associated with amino acid changes) SNPs identified were assessed for associations with lung cancer risk by a caseβcontrol study consisting of 752 adenocar