Microsatellite instability (MSI) caused by deficient DNA mismatch-repair functions is a hallmark of cancers associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome but is also found in about 15% of all sporadic tumors. Most affected microsatellites reside in untranslated inter
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DNA-repair deficient cells identification with a multiwire proportional chamber
โ Scribed by R. Bellazzini; G. Betti; A. Del Guerra; M.M. Massai; M. Ragadini; G. Spandre; G. Tonelli; A. Abbondandolo; S. Bonatti
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 243 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0375-9601
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In addition to playing a role in tumorigenesis, loss of DNA mismatch repair results in low-level intrinsic resistance to cisplatin and carboplatin. We used a mismatch repairdeficient (clone B) and -proficient (clone B/rev) pair of Chinese hamster ovary sublines to determine the ability of cisplatin