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DNA repair defects sensitize cells to anticodon nuclease yeast killer toxins

✍ Scribed by Roland Klassen; Sabrina Wemhoff; Jens Krause; Friedhelm Meinhardt


Book ID
106132402
Publisher
Springer
Year
2010
Tongue
English
Weight
636 KB
Volume
285
Category
Article
ISSN
1617-4615

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Sensitivity to DNA cross-linking chemoth
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Together with tolerance to killing induced by methylating agents, loss of mismatch repair (MMR) has previously been found to be associated with hypersensitivity to the DNAcross-linking agent 1-(2-chloroethyl)-3-cyclohexyl-nitrosourea(CCNU) in several human tumor cell lines (Aquilina et al., 1998). H