โ Scribed by Adayabalam Balajee
No coin nor oath required. For personal study only.
DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.
Cover......Page 1
Copyright......Page 2
Dedication......Page 3
Contents......Page 4
Editor, Contributors......Page 7
Preface......Page 9
CHAPTER 1 - Human Premature Aging Disorders and Dysfunction of DNA Repair......Page 11
CHAPTER 2 - DNA Repair Aspects for RecQ Helicase Disorders......Page 30
CHAPTER 3 - Trichothiodystrophy: A Disorder Highlighting the Crosstalk between DNA Repair and Transcription......Page 40
CHAPTER 4 - Roles of the BRCA1 and BRCA2 Breast Cancer Susceptibility Proteins in DNA Repair......Page 57
CHAPTER 5 - Radiosensitivity of Cells Derived from Down Syndrome Patients: Is Defective DNA Repair Involved?......Page 71
CHAPTER 6 - The Fanconi Anemia/BRCA Pathway: FANCD2 at the Crossroad between Repair and Checkpoint Responses to DNA Damage......Page 77
CHAPTER 7 - Is Ataxia Telangiectasia a Result of Impaired Coordination between DNA Repair and Cell Cycle Cycle Checkpoint Regulators?......Page 92
CHAPTER 8 - Mechanisms of DNA Damage and Repair in Alzheimer Disease......Page 108
CHAPTER 9 - Orchestration of Telomeres and DNA Repair Factors in Mammalian Cells: Implications for Cancer and Ageing......Page 124
CHAPTER 10 - Defective Solar Protection in Xeroderma Pigmentosum and Cockayne Syndrome Patients......Page 138
Index......Page 157
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<p><span>DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries. </span></p>
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