DNA Repair

✍ Scribed by P. E. Verdemato, P. C. E. Moody (auth.), Prof. Dr. Fritz Eckstein, Prof. Dr. David M. J. Lilley (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1998
• Tongue: English
• Leaves: 320
• Series: Nucleic Acids and Molecular Biology 12
• Edition: 1
• Category: Library

✦ Synopsis

DNA is the central repository of genetic information in the cell, yet it is under constant attack by chemical mutagens, radiation and other processes. Cells therefore put a great deal of resources into repairing any damage to this precious store. Mechanisms of DNA repair vary greatly in their level of complexity, from specific reversal mechanisms that involve a single protein, to sequential pathways that require many enzymes. But at the heart of all these mechanisms lie proteins that recognize damage to DNA, raising important questions about how damaged DNA may be distinguished. These recognition processes are now finally yielding their secrets to structural analysis. This volume focuses on DNA repair, with an emphasis on structural data where available.

✦ Table of Contents

Front Matter....Pages I-XI
Repair of Alkylated DNA by the E. coli Ada Protein....Pages 1-27
Structural Phylogenetics of DNA Base Excision Repair....Pages 29-69
Protein Interactions in Mammalian Pathways of DNA Base Excision Repair....Pages 71-82
Poly(ADP-Ribose) Polymerase Is Required for Maintenance of Genomic Integrity During Base Excision Repair....Pages 83-102
Functional Domains of the E. coli UvrABC Proteins in Nucleotide Excision Repair....Pages 103-123
Nucleotide Excision Repair in Yeast: Recent Progress and Implications....Pages 125-139
Nucleotide Excision Repair in Man....Pages 141-155
Transcription-Coupled and Global Genome Nucleotide Excision Repair....Pages 157-172
DNA Mismatch Repair....Pages 173-197
Eukaryotic Mismatch Repair....Pages 199-247
Conflicting Roles of Mismatch and Nucleotide Excision Repair in Cellular Susceptibility to Anticancer Drugs....Pages 249-274
Crystallographic Studies of Proteins Involved in Recombinational Repair and Excision Repair....Pages 275-299
Eukaryotic DNA Ligases and DNA Repair....Pages 301-314
Back Matter....Pages 315-319

✦ Subjects

Cell Biology; Biochemistry, general