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DNA-protective effects of quercetin or naringenin in alloxan-induced diabetic mice

✍ Scribed by Nada Oršolić; Goran Gajski; Vera Garaj-Vrhovac; Domagoj Đikić; Zvjezdana Špacir Prskalo; Damir Sirovina


Book ID
113589195
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
427 KB
Volume
656
Category
Article
ISSN
0014-2999

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DNA-protective effects of quercetin or n
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Diabetes mellitus is associated with a high production of reactive oxygen species, which may cause oxidative DNA damage. High levels of genomic damage have been associated with liver and renal failure as well as immune-system decline. Flavonoids are effective antioxidants and may protect against sev

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## Abstract The purpose of this work was to study the effect of ursodeoxycholic acid (UDCA) on the morphological and functional alterations in pancreatic islet β‐cells in rats with diabetes induced by alloxan (150 mg kg^−1^, i.p.). UDCA (40 mg kg^−1^, i.g.) was administered daily from the fifth to