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DNA polymorphisms of human apolipoprotein A-IV gene: frequency and effects on lipid, lipoprotein and apolipoprotein levels in a French population

✍ Scribed by Mohamed Zaiou; Sophia Visvikis; René Gueguen; Henri-Joseph Parra; Jean Charles Fruchart; Gérard Siest


Book ID
115091614
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
780 KB
Volume
46
Category
Article
ISSN
0009-9163

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Human apolipoprotein A-IV polymorphism:
✍ Hans-Jürgen Menzel; Eric Boerwinkle; Silvia Schrangl-Will; Gerd Utermann 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 527 KB

Human apolipoprotein (apo) A-IV is genetically polymorphic, the apo A-IV polymorphism being controlled by two common alleles, A-IV1 and A-IV2. We have developed a method for typing the apo A-IV polymorphism by Western blotting using polyclonal rabbit antiapo A-IV as the first and gold-labeled antira

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Human apolipoprotein A-IV (apo A-IV) exhibits a genetic polymorphism with two common alleles, A-IV1 and A-IV2, in Caucasian populations. We have investigated this polymorphism in the Icelandic population. The frequencies of the two alleles are significantly different from middel European populations

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Apolipoprotein A-IV phenotypes were determined by reprobing immunoblots initially typed for the apolipoprotein E polymorphism on a representative sample of Mexican-Americans from South Texas. Typings on 331 individuals gave frequency estimates of 0.928, 0.066, 0.003, and 0.003 for alleles 1, 2, 3, a