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DNA Polymorphism of the major histocompatibility class I genes and their association with serologically defined haplotypes

✍ Scribed by A. J. Driesel; K. Römer; F. Schunter; M. D. Laryea; E. M. Schneider; P. Wernet; J. Henke; M. Basler; J. Kömpf

Book ID: 104755248
Publisher: Springer-Verlag
Year: 1985
Tongue: English
Weight: 556 KB
Volume: 21
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00395877

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✦ Synopsis

DNA of unrelated persons as well as members of families that were totally or partially homozygous or completely heterozygous on the loci of the major histocompatibility class I genes has been isolated from peripheral blood lymphocytes and blot hybridized with the class I pseudogene pHLA 12.4 probe. The autoradiographic DNA patterns were discussed and compared with welldefined serological features. Positive associations with serologically typed alleles had been demonstrated for HLA-AI

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