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DNA polymorphism in cytokine genes based on length variation in simple-sequence tandem repeats

✍ Scribed by Chaim O. Jacob; Kirk Mykytyn; Nancy Tashman

Book ID: 104656400
Publisher: Springer-Verlag
Year: 1993
Tongue: English
Weight: 840 KB
Volume: 38
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00188801

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✦ Synopsis

The possibility of the involvement of cytokines in the genetic predisposition to various diseases has been suggested by a large variety of studies. However, the study of potential disease linkage of cytokine genes has been hampered by a lack of sufficiently polymorphic markers at the restriction fragment length polymorphism (RFLP) level. We have investigated the distribution, the length polymorphism, the informativeness, and the efficiency of analysis, of simple-sequence tandem repeats in the mouse cytokine genes. Highly polymorphic sequences have been identified in the

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