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DNA-polymorphic patterns linked to the β-globin genes in German families affected with hemoglobinopathies and thalassemias: a comparison to other ethnic groups

✍ Scribed by Renate Oehme; Elisabeth Kohne; J. Horst

Publisher: Springer
Year: 1985
Tongue: English
Weight: 339 KB
Volume: 71
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00284577

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✦ Synopsis

DNA haplotype constellations of the beta-globin gene cluster have been analyzed in German families with hemoglobinopathies (Hb Freiburg, Hb Köln, Hb Presbyterian) and beta-thalassemias. The polymorphic patterns obtained were compared to those found in families from Greece, Italy, and Turkey affected by beta-thalassemia syndromes. With the combined analysis of seven restriction site polymorphisms a DNA-diagnostic prediction for additional offspring could be made with an overall frequency of 75% in the four ethnic groups.