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DNA polymerase ζ is essential for hexavalent chromium-induced mutagenesis

✍ Scribed by Travis J. O’Brien; Preston Witcher; Bradford Brooks; Steven R. Patierno


Book ID
113809282
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
633 KB
Volume
663
Category
Article
ISSN
0027-5107

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## Abstract Concurrent activation of poly (ADP‐ribose) polymerase (PARP) and DNA ligase was observed in cultured human epidermal keratinocytes (HEK) exposed to the DNA alkylating compound sulfur mustard (SM), suggesting that DNA ligase activation could be due to its modification by PARP. Using HEK,