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DNA Polymerase ζ Introduces Multiple Mutations when Bypassing Spontaneous DNA Damage in Saccharomyces cerevisiae

✍ Scribed by Brian D Harfe; Sue Jinks-Robertson


Book ID
117735998
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
236 KB
Volume
6
Category
Article
ISSN
1097-2765

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr