DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifolia
โ Scribed by Sun, Nan Jun; Woo, Sung Ho; Cassady, John M.; Snapka, Robert M.
- Book ID
- 111952617
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 85 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0163-3864
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DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include bas
Woodfruticosin (I), a new dimeric tannin having an inhibitory activity against DNA topoisomerase 11,was isolated from the methanol extract of Woodfordia fruticosa Kurz (Lythraceae) and its structure was determined by the use of 2D NMR spectroscopy including HMQC and HMBC techniques. As a art of our