𝔖 Bobbio Scriptorium
✦   LIBER   ✦

DNA-ploidy as prognostic factor in prostatic carcinoma

✍ Scribed by O. A. Haugen; O. Mjølnerød

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
547 KB
Volume
45
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

DNA-ploidy in 143 cases of prostatic carcinoma was assessed by flow cytometric analysis of paraffin-embedded biopsy material. The majority of the tumours (64.3%) were diploid, but in advanced sta es the DNA-aneuploidy rate increased from 15 to over 604. No hypoploid tumour was observed and most of the hyperploid tumours were neartetraploid. DNA-aneuploidy was also strongly related to histological grade. Survival analysis using Cox multivariate regression model revealed that low histological grade (high Gleason score), advanced stage and increased level of prostatic acid phosphatase were the most important prognostic factors. DNA-ploidy per se did not contribute independently as a predictor of survival.

📜 SIMILAR VOLUMES

DNA ploidy as a major prognostic factor
DNA ploidy as a major prognostic factor in resectable ampulla of vater cancers
✍ Dr. Yi-Ming Shyr; Cheng-Hsi Su; Li-Hwa Wu; Anna Fen-Yau Li; Jen-Hwey Chiu; Wing- 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 458 KB

The archival paraffin-embedded specimens from 63 ampulla of Vater cancers after pancreaticoduodenectomy between 1965 and 199 I were analyzed by flow cytometry. Of the 63 cancers, 31 (49.2%) were diploid DNA cancers and 32 (50.8%) were aneuploid. Patients with diploid DNA cancer had a median survival

Current prognostic factors for prostate
Current prognostic factors for prostate carcinoma
✍ James E. Montie 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 365 KB 👁 2 views

## BACKGROUND. Prostate carcinoma provides a wide spectrum for risk of death from the disease and clinicians have long sought methods to predict the outcome accurately in individual patients. Traditional prognostic factors, such as histologic grade and stage, remain valuable. Additional clinical a

Prognostic factors in retroperitoneal sa
Prognostic factors in retroperitoneal sarcomas: Ploidy of DNA as a predictor of clinical outcome
✍ Herman, Krzysztof; Grucha?a, Andrzej; Niezabitowski, Aleksander; Gli?ski, Bogdan 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB 👁 2 views

## Background and objectives: Radical surgery is the best mode of treatment of retroperitoneal sarcomas (rs); however, common recurrences are unpredictable. ## Methods: For the better understanding of outcomes and possibilities of treatment retrospective analysis of different factors, including d

The prognostic significance of nuclear d
The prognostic significance of nuclear dna content in prostatic carcinoma
✍ Gun Forsslund; Pier-Luigi Esposti; Bo Nilsson; Anders Zetterberg 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 684 KB

The prognostic significance of ploidy level was studied in prostatic carcinoma and compared with the prognostic significance of morphologic grade and clinical stage. A nonselected group of 145 patients was studied in whom prostatic carcinoma was diagnosed by fine-needle aspiration biopsy at the Karo

c-myc oncogene amplification and cytomet
c-myc oncogene amplification and cytometric DNA ploidy pattern as prognostic factors in musculoskeletal neoplasms
✍ Carlos Barrios; Javier S. Castresana; Ursula G. Falkmer; Ingvar Rosendahl; Andri 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 645 KB

The relationship between c-myc oncogene amplification in neoplastic cells as determined by means of Southern-blot analysis, and their nuclear DNA content as assessed by combined flow and image cytometry, was investigated in fresh tumor specimens from 33 patients with musculoskeletal neoplasms. Ampli