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DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis

โœ Scribed by Taylor, Nicholas P; Zighelboim, Israel; Huettner, Phyllis C; Powell, Matthew A; Gibb, Randall K; Rader, Janet S; Mutch, David G; Edmonston, Tina B; Goodfellow, Paul J


Book ID
109888477
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
205 KB
Volume
19
Category
Article
ISSN
0893-3952

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## Abstract We set out to determine the relative timing of loss of DNA mismatch repair and __KRAS2__ mutation in endometrial tumorigenesis. We studied endometrial carcinoma (CA) and synchronous atypical endometrial hyperplasia (AEH), the premalignant precursor of endometrial cancer. Carcinoma and h