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DNA minor-groove binders: results and design of new antitumor agents

✍ Scribed by Pier Giovanni Baraldi; Barbara Cacciari; Andrea Guiotto; Romeo Romagnoli; Abdel Naser Zaid; Giampiero Spalluto

Book ID
114019446
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
233 KB
Volume
54
Category
Article
ISSN
0014-827X

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## Abstract DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of these compounds form noncovalent complexes with DNA (e.g., distamycin A, Hoechst 33258, and pentamidine) while others DNA‐binding compounds (such as CC‐1065) cause cleavages in the DNA b