DNA microarrays in the clinic: how soon, how extensively?

✍ Scribed by Bertrand R. Jordan

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 105 KB
• Volume: 29
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.20598

✦ Synopsis

Abstract

Although DNA microarrays are now widely used in research settings, they have been slow to penetrate clinical practice in spite of their apparent advantages. This is due to the very different requirements for a clinical test in contrast to a research tool, and to a strict necessity for demonstrated clinical utility. There is a clear differentiation between two types of DNA array tests: “genomic” diagnostics, developed to ascertain the presence or absence of mutations, deletions or duplications, and for which clinical evidence is already established, and tests using expression profiling for prognosis or predictive purposes, in which case the clinical correlate must be proven. Most array diagnostics currently used belong, understandably, to the “genomic” variety. It is to be expected that future improvements in tailored technology, as well as a logical trend towards measuring an ever‐increasing number of parameters, will ensure an important diagnostic role for DNA arrays in the coming decade. BioEssays 29:699–705, 2007. © 2007 Wiley Periodicals, Inc.