DNA methyltransferase expression in the mouse germ line during periods of de novo methylation

Methylation of the O6-methylguanine-DNA

Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol

✍ Rana Abdel-Fattah; Adam Glick; Ishtiaq Rehman; Patrick Maiberger; Henry Hennings 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 212 KB

## Abstract Hypermethylation of CpG sites within the promoter region of the __O^6^‐methylguanine‐DNA methyltransferase__ (__MGMT__) gene occurs frequently in human cancer, preventing both MGMT expression and repair of alkylation damage. To assess the role of MGMT in the development of mouse skin tu