DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma
β Scribed by Hye-Jung Park; Eunsil Yu; Yhong-Hee Shim
- Book ID
- 116333700
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 150 KB
- Volume
- 233
- Category
- Article
- ISSN
- 0304-3835
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## Abstract O^6^βmethylguanineβDNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylationβspecific PCR (MSP)
## Abstract Epigenetic aberration is known to be important in human carcinogenesis. Promoter methylation status of __RAS__ effector related genes, __RASSF1A, RASSF2A, hDAB2IP__ (m2a and m2b regions) and __BLU__, was evaluated in 76 endometrial carcinomas and their nonβneoplastic endometrial tissue
Messenger RNA differential display was used to study liver-gene expression in paired tumor and non-tumor tissues from hepatocellular carcinoma (HCC) patients. mRNA differential display and Northern-blot analyses showed that a 0.8-kb cDNA fragment was diminished or absent from the tumorous tissues of