DNA methylation within the I.4 promoter region correlates with CYPl19A1 gene expression in humanex vivomature omental and subcutaneous adipocytes

Increased DNA methylation in the HoxA5 p

Increased DNA methylation in the HoxA5 promoter region correlates with decreased expression of the gene during tumor promotion

✍ Rebecca E. Watson; Geoffrey M. Curtin; Gary M. Hellmann; David J. Doolittle; Jay 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 478 KB

## Abstract Promoter‐region DNA methylation inhibits transcription. A two‐stage SENCAR (__sen__sitive to mouse __car__cinogenesis) mouse skin carcinogenicity model was used to examine gene‐specific changes in methylation during skin tumor promotion. Analysis was performed on 7,12‐dimethylbenz[a]ant