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DNA methylation profiles in colorectal cancers of Lynch-syndrome patients

โœ Scribed by I. Fridrichova; K. Sebova; A. Alemayehu


Book ID
119598551
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
85 KB
Volume
6
Category
Article
ISSN
1359-6349

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Redundant DNA methylation in colorectal
โœ Aster Alemayehu; Katarina Sebova; Ivana Fridrichova ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 166 KB

## Abstract Lynch syndrome is an inherited disease resulting predominantly in colorectal cancer (CRC). The crucial cause is DNA mismatch repair (MMR) malfunction that is associated mostly with __MLH1__ or __MSH2__ germline mutations. A significant hallmark of repair defects is a high level of insta