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DNA methylation patterns in human tissues of uniparental origin using a zinc-finger gene (ZNF127) from the Angelman/Prader-Willi region

✍ Scribed by Mowery-Rushton, Patricia A.; Driscoll, Daniel J.; Nicholls, Robert D.; Locker, Joseph; Surti, Urvashi

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 28 KB
Volume: 61
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19960111)61:2<140::aid-ajmg7>3.0.co;2-0

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✦ Synopsis

findings of the imprint. Our results suggest that human androgenetic conceptions may provide an excellent model to analyze epigenetic DNA modifications, such as methylation, in imprinted genes. The paternal allele-specific methylation imprint will also be useful clinically to confirm the androgenetic nature of suspected molar conceptions in which parental blood samples may not be available.