DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps
โ Scribed by Elisa Cassinotti; Joshua Melson; Thomas Liggett; Anatoliy Melnikov; Qilong Yi; Charles Replogle; Sohrab Mobarhan; Luigi Boni; Sergio Segato; Victor Levenson
- Book ID
- 112101634
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- French
- Weight
- 279 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0020-7136
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## Abstract Lynch syndrome is an inherited disease resulting predominantly in colorectal cancer (CRC). The crucial cause is DNA mismatch repair (MMR) malfunction that is associated mostly with __MLH1__ or __MSH2__ germline mutations. A significant hallmark of repair defects is a high level of insta