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DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence

✍ Scribed by Marc Andre Nicolas Muschler; Thomas Hillemacher; Cornelia Kraus; Johannes Kornhuber; Stefan Bleich; Helge Frieling

Book ID: 106207696
Publisher: Springer
Year: 2010
Tongue: English
Weight: 278 KB
Volume: 117
Category: Article
ISSN: 1435-1463
DOI: 10.1007/s00702-010-0378-7

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## Abstract ## Background Although the transient nature of transgene expression using first‐generation adenovirus (Ad) vectors is well known, the exact mechanisms responsible for this phenomenon are uncertain. ## Methods Rats were given intramuscular (i.m.) injections of a first‐generation Ad co