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DNA methylation, molecular genetic, and linkage studies in prostate cancer

✍ Scribed by Jarrard, David F.; Bova, G. Steven; Isaacs, William B.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 912 KB
Volume: 29
Category: Article
ISSN: 0270-4137
DOI: 10.1002/(sici)1097-0045(1996)6+<36::aid-pros8>3.0.co;2-i

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✦ Synopsis

Molecular biologic studies have now identified a number of important genetic and epigenetic mechanisms that cause alterations in growth and differentiation genes in prostate cancer. In addition to DNA deletion and point mutation, DNA methylation represents a new paradigm for the inactivation of tumor suppressor or growth suppressor genes. The identification of new genes, including a prostate cancer susceptibility locus, may furnish further insight into the molecular characteristics of prostate cancer and permit the early identification of affected individuals.

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