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DNA Methylation Is Dispensable for the Growth and Survival of the Extraembryonic Lineages

โœ Scribed by Morito Sakaue; Hiroshi Ohta; Yuichi Kumaki; Masaaki Oda; Yuko Sakaide; Chisa Matsuoka; Akiko Yamagiwa; Hitoshi Niwa; Teruhiko Wakayama; Masaki Okano

Book ID
113562996
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
747 KB
Volume
20
Category
Article
ISSN
0960-9822

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Imprinted expression and methylation of
Imprinted expression and methylation of the mouseH19 gene are conserved in extraembryonic lineages
โœ Davis, Tamara L. ;Tremblay, Kimberly D. ;Bartolomei, Marisa S. ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 154 KB

The imprinted H19 gene is hypomethylated on the active maternal allele and hypermethylated on the repressed paternal allele in the somatic tissues of mice and humans. We previously demonstrated that the paternal-specific methylation of a 2 kb region located between ฯช2 and ฯช4 kb relative to the start