The methylation of DNA is an epigenetic modification that can play an important role in the control of gene expression in mammalian cells. The enzyme involved in this process is DNA methyltransferase, which catalyzes the transfer of a methyl group from S-adenosyl-methionine to cytosine residues to f
DNA methylation and mammalian epigenetics
โ Scribed by Wolf Reik; Wendy Dean
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 65 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0173-0835
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DNA methylation is catalyzed by a family of conserved DNA methyltransferases and is widespread among protists, plants, fungi and animals. It is however absent in some species and its genomic distribution varies among organisms. Sequence comparisons suggest that known and putative eukaryotic DNA meth