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DNA Ligase Mutants of Escherichia coli

โœ Scribed by Martin Gellert and Minnie L. Bullock


Book ID
123650057
Publisher
National Academy of Sciences
Year
1970
Tongue
English
Weight
351 KB
Volume
67
Category
Article
ISSN
0027-8424

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Analysis of ligation and DNA binding by
โœ Adam Wilkinson; Andrew Smith; Desmond Bullard; Manuel Lavesa-Curto; Heather Saye ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 598 KB

NAD(+)-dependent DNA ligases are essential enzymes in bacteria, with the most widely studied of this class of enzymes being LigA from Escherichia coli. NAD(+)-dependent DNA ligases comprise several discrete structural domains, including a BRCT domain at the C-terminus that is highly-conserved in thi