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DNA ligase IV is a potential molecular target in ACNU sensitivity

✍ Scribed by Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Taichi Noda; Xiaoming Su; Ken Ohnishi; Peter J. McKinnon; Toshisuke Sakaki; Hiroyuki Nakase; Koji Ono; Takeo Ohnishi

Book ID
108586754
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
249 KB
Volume
101
Category
Article
ISSN
1347-9032

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## Abstract The amplification of the q21 band of chromosome 8 (8q21) occurs in a large percentage of breast cancers. WWP1, an HECT domain‐containing ubiquitin E3 ligase located in the 8q21 region, negatively regulates the TGF‐β tumor suppressor pathway. To characterize the role of __WWP1__ in breas