DNA interstrand crosslinks: Repair, cell signaling, and therapeutic implications
β Scribed by Karen M. Vasquez; Randy J. Legerski
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 32 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.20598
No coin nor oath required. For personal study only.
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## Abstract DNA damage by agents crosslinking the strands presents a formidable challenge to the cell to repair for survival and to repair accurately for maintenance of genetic information. It appears that repair of DNA crosslinks occurs in a path involving double strand breaks (DSBs) in the DNA. M
## Abstract Host cell reactivation assay using Trioxsalenβcrosslinked plasmid pEGFPβN1 showed that human cells were able to repair Trioxsalen interstrand crosslinks (ICL). To study the mechanism of this repair pathway, cells were transfected with the plasmids pEGFPβ1, which did not contain the prom