DNA Interstrand Crosslinks: Natural and Drug-Induced DNA Adducts that Induce Unique Cellular Responses

Relationships among tumor responsiveness

Relationships among tumor responsiveness, cell sensitivity, doxorubicin cellular pharmacokinetics and drug-induced DNA alterations in two human small-cell lung cancer xenografts

✍ G. Pratesi; G. Capranico; M. Binaschi; P. De Isabella; S. Pilotti; R. Supino; F. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 771 KB

In an attempt to understand the underlying cellular/ biochemical factors of sensitivityhesistance in human smallcell lung cancer (SCLC), 2 SCLC tumor lines were compared with respect to tumor responsiveness to drug treatment, cell sensitivity, cellular doxorubicin accumulation, and DNA topoisomerase