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DNA Interactions of the Functionalized (Mixed Polypyridine)ruthenium(II) Complex Bis(2,2′-bipyridine-κN1,κN1′)(methyl dipyrido[3,2-a : 2′,3′-c]phenazine-11-carboxylate-κN4,κN5)ruthenium(2+) ([Ru(bpy)2(dppz-11-CO2Me)]2+)

✍ Scribed by Li-Feng Tan; Fang Wang; Hui Chao; Sheng Zhang; Jun-Jie Fei; Liang-Nian Ji

Publisher: John Wiley and Sons
Year: 2008
Tongue: German
Weight: 320 KB
Volume: 91
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200890136

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✦ Synopsis

Abstract

A novel polypyridine ligand, dipyrido[3,2‐__a:__2′,3′‐c]phenazine‐11‐carboxylic acid methyl ester (=dppz‐11‐CO~2~Me), and its ruthenium(II) complex, [Ru(bpy)~2~(dppz‐11‐CO~2~Me)]^2+^ (1), were synthesized and characterized. The binding properties of this complex to calf‐thymus DNA (CT‐DNA) were investigated by different spectrophotometric methods and viscosity measurements. The results suggest that the complex binds to DNA in an intercalative mode and serves as a molecular ‘light switch’ for DNA. When irradiated at 365 nm, the complex 1 promoted the photocleavage of plasmid pBR‐322 DNA.

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## Abstract The complex __trans__‐[RuCl~2~{κ^2^‐__P__,__P__‐(__S__)‐peap}~2~] (1) has been stereoselectively prepared by the treatment of a stoichiometric mixture of complex [RuCl~2~(DMSO)~4~] (DMSO = dimethyl sulfoxide) and (__S__)‐peap [(__S__)‐peap = (−)‐__N__,__N__‐bis(diphenylphosphanyl)‐(__S_