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DNA interaction, free radical scavenging and in-vitro antibacterial activity of drug-based copper(II) complexes

✍ Scribed by Mohan N. Patel; Promise A. Dosi; Bhupesh S. Bhatt

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 263 KB
Volume: 25
Category: Article
ISSN: 0268-2605
DOI: 10.1002/aoc.1817

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✦ Synopsis

Abstract

The Cu(II) complexes of type [Cu(cpf)(A^n^)Cl] (A^n^ = terpyridines, cpf = ciprofloxacin) were synthesized and characterized using IR, mass and reflectance spectra. The free ligands and their complexes were evaluated for their in‐vitro antimicrobial activity against a panel of Gram‐positive and Gram‐negative bacteria. The complexes exhibit better or equal inhibition in comparison to free fluoroquinolones. Binding interactions of the complexes with calf thymus (CT DNA) were investigated by absorption titration, viscosity studies and DNA melting temperature experiment. The cleavage reaction on pUC19 DNA was monitored by agarose gel electrophoresis. The lower concentration of the complexes was catalysed the dismutation of superoxide radical at biological pH, which indicates that the complexes can act as a possible model for superoxide dismutase. Copyright © 2011 John Wiley & Sons, Ltd.

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