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DNA index of glial tumors in children: Correlation with tumor grade and prognosis

✍ Scribed by Prasad Mathew; Thomas Look; Xiaolong Luo; Richard Ashmun; Michael Nash; Amar Gajjar; Andrew Walter; Larry Kun; R. L. Heideman

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 507 KB
Volume: 78
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960815)78:4<881::aid-cncr27>3.0.co;2-q

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✦ Synopsis

BACKGROUND.

Although DNA index (DI) has prognostic significance in a variety of pediatric malignancies, there are few data regarding its utility in central nervous system (CNS) tumors. We have previously shown that patients with hyperdiploid medulloblastoma have a significantly better survival than those whose tumors are diploid. Here, we examine the effect of DI and tumor grade on the progression free survival (PFS) of 57 patients with a variety of glial neoplasms. METHODS. DI was determined by flow cytometry on freshly obtained tumor tissue from the initial diagnostic specimens; a DI = 1.0 was defined as diploid (DIP),

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