Mechanisms and modulation of resistance
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Raymond P. Perez; Thomas C. Hamilton; Robert F. Ozols; Robert C. Young
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Article
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1993
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John Wiley and Sons
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English
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Chemotherapy for advanced ovarian cancer remains suboptimal. Despite the improvements in objective response rates realized with cisplatin-based combination chemotherapeutic regimens, most patients still die of refractory cancer. Drug resistance has emerged as the single most important determinant of