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DNA haplotype dependency of debrisoquine 4-hydroxylase (CYP2D6) expression among extensive metabolisers

✍ Scribed by C. Mura; S. Panserat; M. Vincent-Viry; M. M. Galteau; E. Jacqz-Aigrain; R. Krishnamoorthy


Book ID
105134294
Publisher
Springer
Year
1993
Tongue
English
Weight
610 KB
Volume
92
Category
Article
ISSN
0340-6717

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DNA haplotype-dependent differences in t
✍ S. Panserat; C. Mura; N. GΓ©rard; M. Vincent-Viry; M. M. Galteau; E. Jacqz-Aigrai πŸ“‚ Article πŸ“… 1994 πŸ› Springer 🌐 English βš– 785 KB

The molecular basis for DNA haplotype-dependent debrisoquine 4-hydroxylase (CYP2D6) expression was explored by sequencing all of the nine exons of the CYP2D6 gene. Two distinct exon sequence frameworks of the CYP2D6 gene were found, each associated with specific BamHI-defined DNA haplotypes of the C