DNA fingerprint analysis in development and progression of human solid tumors
β Scribed by R. Dahse; F. v. Eggeling; G. Ernst; H. Kosmehl; A. Schlichter; J. Schubert; U. Claussen
- Book ID
- 113253510
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 76 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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DNA histograms were measured by flow cytometry for 656 human solid tumors (365 primary and 291 metastatic). The proportion of aneuploid cells in cell suspensions obtained by mechanical disaggregation was significantly higher than those obtained after enzymatic disaggregation (collagenase + DNAse) of
## Abstract DNA fingerprint analysis was used to study structural abnormalities in the genome of mouse liver tumor cells. Liver tumors were induced in three strains of mice, namely C57BL/6J, C3H/He and B6C3F~1~, by a single injection of 20 ΞΌg/g body wt. diethylnitrosamine on day 15 after birth. DNA