## Abstract DNA double‐strand breaks (DSBs) are the most hazardous lesions arising in the genome of eukaryotic organisms, and yet occur normally during DNA replication, meiosis, and immune system development. The efficient repair of DSBs is crucial in maintaining genomic integrity, cellular viabili
✦ LIBER ✦
DNA double-strand breaks: their cellular and clinical impact?
✍ Scribed by Jeggo, P A; Löbrich, M
- Book ID
- 110072853
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 86 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Two mechanisms are available for the repair of DNA double‐strand breaks (DSBs) in eukaryotic cells: homology directed repair (HDR) and non‐homologous end‐joining (NHEJ). While NHEJ is not restricted to a particular phase of the cell cycle, it is incapable of accurately repairing DBSs th