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DNA-damaging ability of isoprene and isoprene mono-epoxide (EPOX I) in human cells evaluated with the comet assay

✍ Scribed by Roberto Fabiani; Patrizia Rosignoli; Angelo De Bartolomeo; Raffaela Fuccelli; Guido Morozzi

Book ID: 116759253
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 371 KB
Volume: 629
Category: Article
ISSN: 1383-5718
DOI: 10.1016/j.mrgentox.2006.12.007

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Paclitaxel is a recent chemotherapeutic agent that inhibits tubulin depolymerization in tumoral cells. Despite its increasing use against various human cancers, the genotoxicity of paclitaxel has never been studied on normal human cells. The in vitro genotoxic effects of the drug were evaluated with