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DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells


Book ID
117659890
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
153 KB
Volume
38
Category
Article
ISSN
0959-8049

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## Abstract Methylxantine derivative, caffeine, is known to prevent the p53‐dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser‐15 residue. In contrast, it has been reported that caffeine induces p53‐mediated ap