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DNA damage induced by cis- and carboplatin as indicator for in vitro sensitivity of ovarian carcinoma cells

✍ Scribed by Florian T Unger; Hermann A Klasen; Garri Tchartchian; Rudy L de Wilde; Irene Witte


Book ID
115011719
Publisher
BioMed Central
Year
2009
Tongue
English
Weight
599 KB
Volume
9
Category
Article
ISSN
1471-2407

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The level of DNA adducts under the same conditions of carcinogen exposure and cell proliferation reflects an integrated measure of carcinogen metabolism and DNA repair. Therefore, such DNA adduct levels have the potential to be a biomarker for susceptibility to chemical carcinogenesis. In a pilot st