Catechol estrogens induce oxidative DNA
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Yusuke Hiraku; Naruto Yamashita; Meiko Nishiguchi; Shosuke Kawanishi
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Article
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2001
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John Wiley and Sons
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French
โ 153 KB
Estrogen-induced carcinogenesis involves enhanced cell proliferation (promotion) and genotoxic effects (initiation). To investigate the contribution of estrogens and their metabolites to tumor initiation, we examined DNA damage induced by estradiol and its metabolites, the catechol estrogens 2-hydro