DNA damage in exfoliated cells and histopathological alterations in the urinary tract of mice exposed to cigarette smoke and treated with chemopreventive agents

Preneoplastic and neoplastic lesions in

Preneoplastic and neoplastic lesions in the lung, liver and urinary tract of mice exposed to environmental cigarette smoke and UV light since birth

✍ Francesco D'Agostini; Roumen Balansky; Vernon E. Steele; Gancho Ganchev; Carlo P 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 90 KB 👁 2 views

## Abstract It is difficult to reproduce the carcinogenicity of cigarette smoke (CS) in animal models. Recently, we showed that exposure of mice to mainstream CS (MCS) for 120 days, starting immediately after birth, resulted in an early and potent carcinogenic response. In parallel, we implemented