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DNA-damage, cell-cycle arrest and apoptosis induced in BEAS-2B cells by 2-hydroxyethyl methacrylate (HEMA)

✍ Scribed by V. Ansteinsson; A. Solhaug; J.T. Samuelsen; J.A. Holme; J.E. Dahl

Book ID
116759939
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
988 KB
Volume
723
Category
Article
ISSN
1383-5718

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## Abstract 2‐Methoxyestradiol (2ME) is an endogenous metabolite with estrogen receptor‐independent anti‐tumor activity. The current study seeks to determine the mechanism of anti‐tumor activity of 2ME on human chondrosarcoma. 2ME caused a time‐ and dose‐dependent cytotoxity in chondrosarcoma cells