𝔖 Bobbio Scriptorium
✦   LIBER   ✦

DNA damage and cellular differentiation: More questions than responses

✍ Scribed by Marta Simonatto; Lucia Latella; Pier Lorenzo Puri

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
134 KB
Volume
213
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Studies on DNA damage responses in proliferating cells have revealed the relationship between sensing and repair of the DNA lesions and the regulation of the cell cycle, leading to the discovery and molecular characterization of the DNA damage‐activated cell cycle checkpoints. Much less is known about the DNA damage response in progenitors of differentiated cells, in which cell cycle arrest is a critical signal to trigger the differentiation program, and in terminally differentiated cells, which are typically post‐mitotic. How DNA lesions are detected, processed and repaired in these cells, the functional impact of DNA damage on transcription of differentiation‐specific genes, how these events are coordinated at the molecular level, the consequence of defective DNA damage response on tissue‐specific functions and its potential relationship with age‐related diseases are currently open questions. In particular the biological complexity inherent to the global genome reprogramming of tissue progenitors, such as embryonic or adult stem cells, suggests the importance of an accurate DNA damage response at the transcription level in these cells to ensure the genomic integrity of regenerating tissues. J. Cell. Physiol. 213:642–648. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Direct Cellular Responses to Platinum-In
Direct Cellular Responses to Platinum-Induced DNA Damage
✍ Yongwon Jung; Stephen J. Lippard 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 11 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

BTG gene expression in the p53-dependent
BTG gene expression in the p53-dependent and -independent cellular response to DNA damage
✍ Ulrich Cortes; Caroline Moyret-Lalle; Nicole Falette; Cyril Duriez; Fatiha El Gh 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage, transduce the signal, and ultimately delay the cell cycle or trigger apoptosis. Recently, we have shown that BTG2/TIS21 gene expression was indu

Differential response to UV stress and D
Differential response to UV stress and DNA damage during the yeast replicative life span
✍ Kale, Shubha P. ;Jazwinski, S. Michal 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 757 KB

The yeast Saccharomyces cerevisiae is mortal. Before they die, individual yeasts bud repeatedly producing a finite number of progeny, which have the capacity for a full life span. A feature of aging in many species is the waning of resistance to stress. To determine whether this is the case in yeast

Alterations in the molecular response to
Alterations in the molecular response to DNA damage during cellular aging of cultured fibroblasts: Reduced AP-1 activation and collagenase gene expression
✍ Augustine M. K. Choi; Robert J. Pignolo; Colette M. J. Ap Rhys; Vincent J. Crist 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 993 KB

Transcriptional activation of c-fos in response to both serum stimulation and D N A damage requires the serum response element. The inability of in vitro aged or senescent fibroblasts to proliferate in response to serum has been shown to be associated with repressed c-fos expression and reduced AP-1

Forced activation of Stat5 subjects mamm
Forced activation of Stat5 subjects mammary epithelial cells to DNA damage and preferential induction of the cellular response mechanism during proliferation
✍ Tali Eilon; Itamar Barash 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 540 KB

## Abstract Parity‐dependent adenocarcinoma tumors developed in postestropausal transgenic mice expressing a constitutively active Stat5 variant (STAT5ca) in their mammary gland. These tumors maintained elevated expression levels of genes regulating the cellular DNA damage response (DDR) mechanism,

Murine dendritic cells transfected with
Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8+ and CD4+ T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity
✍ Sixun Yang; Carol E. Vervaert; James Burch; Jr.; James Grichnik; Hilliard F. Sei 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 196 KB 👁 2 views

Dendritic cells (DCs) are potent inducers of cytotoxic T lymphocytes (CTLs) when pulsed with an antigenic peptide or tumor lysate. In this report, we have used liposomemediated gene transfer to examine the ability of plasmid DNA encoding the human melanoma-associated antigen gp100 to elicit CD8 ؉ an