𝔖 Bobbio Scriptorium
✦   LIBER   ✦

DNA Conformation and Protein Binding

✍ Scribed by Travers, A A


Book ID
111647592
Publisher
Annual Reviews
Year
1989
Tongue
English
Weight
858 KB
Volume
58
Category
Article
ISSN
0066-4154

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The transcription factor p53 controls the proliferation and survival of cells exposed to DNA damage. The specific DNA-binding domain of p53 (residues 102-292) has a complex tertiary structure that is stabilized by zinc. In this study, we showed that exposure of cultured cells to the membrane-permeab

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## Abstract Id proteins are dominant negative regulators of the helix–loop–helix (HLH) transcription factors and are important during development, especially by preventing cell differentiation while inducing cell proliferation. In contrast, they are poorly expressed in healthy adults but are found