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DNA binding property, nuclease activity and cytotoxicity of Zn(II) complexes of terpyridine derivatives

✍ Scribed by Qin Jiang; Jianhui Zhu; Yangmiao Zhang; Nan Xiao; Zijian Guo

Publisher
Springer Netherlands
Year
2008
Tongue
English
Weight
327 KB
Volume
22
Category
Article
ISSN
1572-8773

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## Abstract Two copper(II) terpyridine complexes, [Cu(atpy)(NO~3~)(H~2~O)](NO~3~) β‹… 3H~2~O (1) and [Cu(ttpy)(NO~3~)~2~] (2) (atpy = 4′‐__p__‐N9‐adeninylmethyl‐phenyl‐2,2β€²:6,2″‐terpyridine; ttpy = 4′‐__p__‐tolyl‐2,2β€²:6,2″‐terpyridine) exhibited high cytotoxicity, with average ten times more potency