DNA Binding Properties of Novel Distamycin Analogs That Lack the Leading Amide Unit at the N-Terminus

Facile synthesis of oligopeptide distamy

Facile synthesis of oligopeptide distamycin analogs devoid of hydrogen bond donors or acceptors at the N-terminus: sequence-specific duplex DNA binding as a function of peptide chain length

✍ Santanu Bhattacharya; Mini Thomas 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 146 KB

The ®rst examples of distamycin analogs, which lack hydrogen bond interactor groups at the N-terminus, have been synthesized. The bispyrrole peptide did not exhibit any detectable binding with double-stranded (ds) DNA. However, all other homologues did bind to ds-DNA strongly, with the binding aniti