𝔖 Bobbio Scriptorium
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Dna binding and its relationship to carcinogenesis by different polycyclic hydrocarbons

✍ Scribed by Eliezer Huberman; Leo Sachs

Book ID
102277382
Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
446 KB
Volume
19
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Five different polycyclic hydrocarbons with different degrees of carcinogenicity in vivo were tested for their metabolism to water‐soluble products and their binding to DNA, RNA and protein in normal embryonic hamster and BHK cells. The compounds studied were 7,12‐dimethyl‐benz(a)anthracene, benzo(a)pyrene, 20‐methyl‐cholanthrene, dibenz(a,h)anthracene and dibenz‐(a,c)anthracene. All five compounds were metabolized to water‐soluble products in both types of cells and treatment of cells with aminophylline enhanced this metabolism. After and not before this enhancement of metabolism by aminophylline, there was a relationship between the degree of carcinogenicity and binding to DNA. There was no such relationship with binding to RNA or protein. The results, indicating a relationship between the degree of carcinogenicity and binding to DNA under appropriate conditions of metabolism, support the suggestion that DNA is the target for carcinogenesis by such carcinogens.

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