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Dna autosensitivity in two japanese sisters

✍ Scribed by Susumu Sugai; Yukio Yasuda; Shiro Shimizu; Makoto Sawada; Junko Tachibana; Susumu Konda; Hirohisa Kitada; Hiroko Nakaizumi; Sadao Tsukada

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 555 KB
Volume: 33
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780330221

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✦ Synopsis

Two cases of DNA autosensitivity in Japanese sisters are reported. Both patients developed painful ecchym o m and other bleeding disorders. Skin tests with autologous leukocyte lysates and calf thymus DNA produced intermediate-type reactions that were identical to spontaneous skin reactions. Pretreatment of DNA with either DNase or chloroquine sulfate inhibited these reactions. Our studies suggest that anti-DNA antibodies might contribute to the clinical symptoms of this disorder.

DNA autosensitivity is a rare disorder that was first reported by Levin and Pinkus in 1961 (1). It is characterized by recurrent, painful ecchymoses of the extremities and intermediate-type skin reactions to lysed autologous leukocytes and to heterologous DNA. To our knowledge, at least 9 cases have been reported (1-9). However, the pathophysiology of this disorder has remained obscure. In 1982, we reported a Japanese patient with DNA autosensitivity (9), whose younger sister developed the same disorder 1 year later. We report herein the clinical observations on these 2 sisters with DNA autosensitivity and suggest

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